• Users Online: 221
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 34  |  Issue : 2  |  Page : 107-113

Evaluation of serum level of visfatin among psoriatic patients


1 Department of Dermatology, Venereology and Andrology, Alexandria University, Alexandria, Egypt
2 Department of Clinical Pathology, Alexandria University, Alexandria, Egypt
3 Faculty of Medicine, University of Baghdad, Baghdad, Iraq

Correspondence Address:
Rasha Mahmoud Genedy
No. 9, 10th Floor, University Buildings, Smouha, Alexandria
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-6530.150264

Rights and Permissions

Introduction Psoriasis is a common chronic inflammatory skin condition that varies in severity. Psoriasis is associated with the complex disorder of metabolic syndrome, which incorporates hypertension, dyslipidemia, obesity, and impaired glucose tolerance, and the association is stronger for severe psoriasis compared with mild psoriasis. Adipose tissue is an important endocrine organ; it secretes several hormones and cytokines that are involved in the metabolic syndrome. Visfatin is a 52-kDa protein secreted primarily by visceral fat. Various cells such as neutrophils, monocytes, macrophages as well as epithelial and endothelial cells might be a source of visfatin after induction with inflammatory stimuli. Aim The aim of this work was to evaluate the serum levels of visfatin in psoriatic patients and its relation to the duration, severity of psoriasis, and BMI. Patients and methods This study was carried out on 40 psoriatic patients and 40 normal healthy control participants. Venous samples were obtained to measure the serum visfatin level using the ELISA technique. Results The serum level of visfatin in the patient group was statistically significantly higher than the serum level of visfatin in the control group. In addition, there was a positive significant correlation between the serum level of visfatin and the PASI score (R = 0.951, P = 0.0001). There was a positive significant correlation between the serum level of visfatin and the duration of psoriasis (R = 0.942, P = 0.0001). Conclusion This study concluded that visfatin is one of the adipokines that may play a role in the pathogenesis of psoriasis and its severity in addition to its role in diseases of the cardiovascular system, which could also explain the relation between psoriasis and cardiovascular complications and their severity in psoriatic patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1522    
    Printed47    
    Emailed0    
    PDF Downloaded172    
    Comments [Add]    

Recommend this journal