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Year : 2015  |  Volume : 35  |  Issue : 2  |  Page : 59-64

Assessment of serum homocysteine level in patients with nonsegmental vitiligo

1 Department of Dermatology, Venereology and Andrology, Alexandria Faculty of Medicine, Alexandria, Egypt
2 Department of Clinical and Chemical Pathology, Alexandria Faculty of Medicine, Alexandria, Egypt
3 Ministry of Health Hospital, Alexandria, Egypt

Correspondence Address:
Carmen I Farid
MD, El-Areesh Street No. 2, Smooha, Alexandria
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-6530.178461

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Aim To evaluate the serum level of homocysteine in non-segmental vitiligo cases compared to controls and its relation to the progression of the disease. Subjects and methods Serum Hcy levels were assessed in 40 patients diagnosed with non-segmental vitiligo (active and stable) in comparison to 40 age and sex matched healthy controls, using enzyme immunoassay technique (EIA). Relation to disease clinical phenotype, extent, severity and progression was assessed. Results An insignificantly higher level of serum homocysteine was detectable in vitiligo patients compared to controls. Patients with progressive disease had significantly higher levels than those with stable course. No significant relation was found to clinical phenotype, extent or clinical severity of the disease. Conclusion Hyperhomocysteinemia cannot be considered as a risk factor for development of non-segmental vitiligo, but it contributes to its activity and progression. It is not related to disease clinical phenotype, extent or severity.

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