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ORIGINAL ARTICLE
Year : 2017  |  Volume : 37  |  Issue : 1  |  Page : 11-14

Level of serum soluble endothelial leukocyte adhesion molecule-1 in psoriatic patients after narrow-band ultraviolet-B and relation to disease activity: a case–control study


1 Department of Dermatology, Venereology, and Andrology, Ain Shams University, Cairo, Egypt
2 Poison Control Center, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Ghada Fathy
7 El-Menya Street, Heliopolis, Cairo, 11341
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-6530.207486

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Context Endothelial leukocyte adhesion molecule-1 (E-selectin) is expressed on endothelial cells in psoriasis vulgaris (PV). Alteration in E-selectin is one of the influential proinflammatory cytokines in the pathogenesis of psoriasis. Aims This study aimed to assess the serum level of E-selectin and to determine the effect of narrow-band ultraviolet-B (UVB) therapy on serum E-selectin levels in patients with psoriasis and to assess the relationship between serum E-selectin levels and disease activity after this treatment. Settings and design This was a case–control study. Patients and methods Thirty-five patients with chronic plaque psoriasis and 35 age-matched and sex-matched healthy controls were included. The concentration of soluble E-selectin (sE-selectin), determined by enzyme-linked immunosorbent assay was studied in the sera of patients before and after narrow-band UVB treatment sessions (three times per week for 3 months) and compared with normal nonpsoriatic controls. The disease severity was established using the Psoriasis Area and Severity Index scoring system. Results Levels of sE-selectin were significantly increased in the sera of patients with atopic dermatitis and psoriasis (compared with the controls). Clinical improvement, after treatment, in patients with PV was associated with a significant decrease in the serum levels of sE-selectin. There was a significant correlation of sE-selectin and disease activity in PV patients. Conclusion E-selectin might be an indicator of treatment response and acts as a marker of psoriatic disease activity; it is also suggested to be a useful tool for evaluating the efficacy of treatment by narrow-band UVB in patients with psoriasis.


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