| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 33
| Issue : 2 | Page : 67-70 |
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Expression of interleukin-17 mRNA in vitiligo patients
Ahmed M Habeb1, Al Hassan M Al Hefnawy1, Shereen B Elsayed2, Amira Abd El-rahman Abo Bkr3, Alhasan M Elhefnawy3
1 Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt
2 Department of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Correspondence Address:
Alhasan M Elhefnawy
Faculty of Medicine, Ain Shams University, 7 Thawra sq, Dokki, Cairo, Postal code: 12311
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1110-6530.123951
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Background
Vitiligo is a specific type of idiopathic acquired or inherited leukoderma which is characterized by patterned/circumscribed hypomelanosis of the skin and hair, with complete absence of melanocytes. The aetiology of vitiligo is unknown, several hypotheses have been proposed to explain its pathogenesis and a convergence theory was proposed which assumes that all hypotheses are not mutually exclusive. In vivo, immunohistochemical studies of perilesional area of active lesions in generalized vitiligo mainly detects predominant CD8+ and to lesser extent CD4+ T cells in the infiltrate, which express activation molecules such as the skin homing receptor; CLA antigen and the IL-17. IL17 mRNA is up-regulated in the blood of vitiligo patients therefore, it has been suggested as a crucial regulator of vitiligo.
Aim of work
In this study, we focused primarily on the regulatory pathways and role of IL-17 in vitiligo by determination of the level of expression of IL17 mRNA by Real-time RT-PCR. |
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