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Year : 2014  |  Volume : 34  |  Issue : 1  |  Page : 53-57

Study of oxidative stress in different clinical severities of acne vulgaris

1 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt
2 Department ofClinical and Chemical Pathology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

Correspondence Address:
Magdy A Ragab
MD, Department of Dermatology, Venereology and Andrology, Faculty of Medicine, University of Alexandria, 21599 Alexandria
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-6530.137313

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Background Acne vulgaris is a multifactorial disease, but recent studies have focused on the role of oxygen free radicals and antioxidant enzymes. Malondialdehyde (MDA) is the end product of lipid peroxidation and is a good marker of free radical-mediated damage and oxidative stress. Superoxide dismutase (SOD) represents the major cellular defense against superoxide anions. Objective The objective of this study was to study the role of oxidative stress in acne vulgaris and to detect a possible link with the different clinical severities. Patients and methods Fifty patients with acne vulgaris and 20 healthy controls were included in this study. The severity of the disease was assessed using the Global Acne Grading System. The levels of SOD in erythrocytes and MDA in plasma were measured using a spectrophotometer. Results Although higher SOD levels and mean values were present in patients, there was no statistically significant difference compared with the controls. MDA levels showed a significant difference between patients and controls (P < 0.05), with MDA being higher in patients, indicating a condition of oxidative stress that had resulted from a high level of lipid peroxidation in acne patients. Comparison of SOD levels in patients showed that patients with severe acne had the lowest levels in comparison with patients with mild and moderate acne (P < 0.001). SOD levels were the highest in patients with mild acne. In terms of MDA levels, patients with severe acne showed the highest plasma MDA levels compared with those with mild and moderate (P < 0.05) acne, suggesting an increase in reactive oxygen species production overwhelming the antioxidant capacity. The lowest MDA levels were observed in mild acne. Conclusion Oxidative stress may play a role in the etiopathogenesis of acne and⁄or the progression of the disease. Coadministration of antioxidant drugs with various lines of treatment of acne might be helpful, especially for those with inflammatory lesions.

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