| ORIGINAL ARTICLE |
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| Year : 2014 | Volume
: 34
| Issue : 2 | Page : 107-113 |
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Evaluation of serum level of visfatin among psoriatic patients
Fayrouz Khalil Badran1, Rasha Mahmoud Genedy1, Rania Shafik Swelem2, Muhannad Ziad Al-Rawi3
1 Department of Dermatology, Venereology and Andrology, Alexandria University, Alexandria, Egypt
2 Department of Clinical Pathology, Alexandria University, Alexandria, Egypt
3 Faculty of Medicine, University of Baghdad, Baghdad, Iraq
Correspondence Address:
Rasha Mahmoud Genedy
No. 9, 10th Floor, University Buildings, Smouha, Alexandria
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1110-6530.150264
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Introduction
Psoriasis is a common chronic inflammatory skin condition that varies in severity. Psoriasis is associated with the complex disorder of metabolic syndrome, which incorporates hypertension, dyslipidemia, obesity, and impaired glucose tolerance, and the association is stronger for severe psoriasis compared with mild psoriasis. Adipose tissue is an important endocrine organ; it secretes several hormones and cytokines that are involved in the metabolic syndrome. Visfatin is a 52-kDa protein secreted primarily by visceral fat. Various cells such as neutrophils, monocytes, macrophages as well as epithelial and endothelial cells might be a source of visfatin after induction with inflammatory stimuli.
Aim
The aim of this work was to evaluate the serum levels of visfatin in psoriatic patients and its relation to the duration, severity of psoriasis, and BMI.
Patients and methods
This study was carried out on 40 psoriatic patients and 40 normal healthy control participants. Venous samples were obtained to measure the serum visfatin level using the ELISA technique.
Results
The serum level of visfatin in the patient group was statistically significantly higher than the serum level of visfatin in the control group. In addition, there was a positive significant correlation between the serum level of visfatin and the PASI score (R = 0.951, P = 0.0001). There was a positive significant correlation between the serum level of visfatin and the duration of psoriasis (R = 0.942, P = 0.0001).
Conclusion
This study concluded that visfatin is one of the adipokines that may play a role in the pathogenesis of psoriasis and its severity in addition to its role in diseases of the cardiovascular system, which could also explain the relation between psoriasis and cardiovascular complications and their severity in psoriatic patients. |
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