• Users Online: 231
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2014  |  Volume : 34  |  Issue : 2  |  Page : 93-97

Plasma level of α-melanocyte-stimulating hormone in atopic dermatitis patients

1 Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt

Correspondence Address:
Nashwa N El Far
MD, Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-6530.150257

Rights and Permissions

Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intense pruritus with marked exacerbation and remission. α-Melanocyte-stimulating hormone (α-MSH) is a neuropeptide produced at different sites including the skin. It has immunomodulatory and anti-inflammatory properties. However, its role in the etiopathogenesis of AD still remains largely unclear. Objective The aim of this work was to evaluate the plasma level of α-MSH in patients with AD to assess its role in the severity of the disease. Patients and methods This study included 30 patients with AD whose severity of disease was assessed by means of the scoring atopic dermatitis (SCORAD) score, in addition to 18 healthy individuals who served as controls. Blood samples were taken from all patients and controls for detection of plasma α-MSH level by means of the enzyme-linked immunosorbent assay. Results A highly significant increase was found in the mean plasma α-MSH level of AD patients compared with controls. Further, the plasma α-MSH level was significantly positively correlated with the severity of AD. Conclusion T he mean plasma α-MSH level in AD patients was significantly higher than that in normal healthy controls. Moreover, the plasma α-MSH level showed a significant positive correlation with disease severity.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded601    
    Comments [Add]    

Recommend this journal