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Year : 2014  |  Volume : 34  |  Issue : 2  |  Page : 98-101

Combined cryotherapy and topical 5-fluorouracil for treatment of basal cell carcinoma

1 Dermatology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Cairo, Egypt
2 Cairo Hospital for Dermatology & Venereology, 'Al-Haud Al-Marsoud', Cairo, Egypt

Correspondence Address:
Ahmed Sadek
MSc, 5 Lateef Basha Seelim St., Off AlNozha St., Heliopolis, 11341, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-6530.150259

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Background Cryotherapy (Cryo) and topical 5-fluorouracil (5FU) are both considered as successful noninvasive therapeutic options for basal cell carcinoma (BCC). Objective The aim of the study was to investigate the efficacy of combined Cryo and topical 5FU (Cryo+5FU) in patients suffering from BCC. Design This was a prospective clinical trial with a 6-month follow-up. Duration The study was carried out during a period of 11 months from March 2012 to February 2013. Patients and methods Fifteen patients complaining of BCC were included. Intervention Intervention included combined weekly regimen of Cryo followed after 3 days by twice daily 5FU application for four successive days for a maximum of 6 weeks. Main outcome measures Assessments of clinical improvement by examination, dermatological photography, and skin biopsy were the main outcome. Results All 15 patients achieved complete response with minimal side effects, good cosmetic outcome, and relatively shorter duration of treatment. Conclusion Combined Cryo+5FU offers a new effective modality for treatment of BCC.

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