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Year : 2016  |  Volume : 36  |  Issue : 2  |  Page : 60-62

A resistant case of pyoderma gangrenosum with monoclonal gammopathy of unknown significance showing excellent response to combination therapy of methyl prednisolone pulse and oral cyclosporine

1 N.R.S. Medical College and Hospital, Kolkata, India
2 Kolkata Medical College and Hospital, Kolkata, India
3 Department of Dermatology, Venereology and Leprosy, N.R.S. Medical College and Hospital, Kolkata, India

Correspondence Address:
Najmus S Jamadar
Kolkata Medical College and Hospital, A 4.1 N.B.C.C, Vibgyor Tower, Newtown, Rajarhat, Kolkata 700156, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-6530.202641

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Pyoderma gangrenosum (PG) is a rare and painful skin condition of uncertain etiology characterized by one or more areas of chronic ulceration with well-demarcated and undermined borders. PG often occurs in patients who have other diseases (arthritis, inflammatory bowel disease, hematologic dyscrasias, monoclonal gammopathy of unknown significance, etc). Immunosuppressive agents have been used for its management. Among them, although corticosteroid is known as the most effective agent, other immunosuppressants including cyclosporine have been selected for patients with PG who were refractory to systemic steroids. Here, we report a case of PG with monoclonal gammopathy of unknown significance, resistant to systemic steroids and cyclosporine, that was successfully treated with a combination of cyclosporine and methyl prednisolone pulse.

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