• Users Online: 165
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2021  |  Volume : 41  |  Issue : 1  |  Page : 22-25

Role of autophagy in nonsegmental vitiligo Naguid and Rashed

1 Department of Dermatology and Venerology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
2 Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Rehab M Naguib
Department of Dermatology, Beni-Suef, 19 Port Saed Street 62511
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejdv.ejdv_9_20

Rights and Permissions

Background Vitiligo is a skin and less common hair disease characterized by decline in melanocyte function and depigmentation, with a prevalence of 0.5–1% in most populations. Autophagy is the degradation of components of the cytoplasm within lysosomes. This is distinct from endocytosis-mediated lysosomal degradation of extracellular and plasma membrane proteins. Aim The aim was to detect biochemical parameter light chain 3 (LC3) to monitor autophagy in vitiligo skin of patients as compared with normal control persons to evaluate the role of autophagy in the vitiligo pathogenesis. Materials and methods This case–control study included 60 patients with vitiligo and 60 age-matched and sex-matched healthy controls. Herein, 4 mm punch skin biopsy was taken from every patient (vitiligo lesion) and control and kept in lysis solution for the stability of the studied parameters and was kept frozen at −80°C till analysis of autophagy protein LC3 by qRT PCR. Results The level of LC3 in lesional skin of vitiligo was significantly lower as compared with normal control persons.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded155    
    Comments [Add]    
    Cited by others 1    

Recommend this journal