| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 42
| Issue : 3 | Page : 151-154 |
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The importance of micro-RNA 224-3p in pathogenesis of NonSegmental Vitiligo
Rehab M Naguib1, Hanan A Ibrahim2, Laila A Rashed3, Abd-El A El-Rifaie1
1 Department of Dermatology & Venerology, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt
2 Department of Dermatology, Beni-Suef General Hospital, Ministry of Health, Beni-Suef, Egypt
3 Department of Biochemistry, Cairo University, Cairo, Egypt
Correspondence Address:
MD Rehab M Naguib
Department of Dermatology & Venerology, Faculty of Medicine, Beni-Suef University, Beni Suef
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ejdv.ejdv_35_21
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Background Vitiligo is a skin and less common hair disease characterized by a decline in melanocyte function with a prevalence of 0.5–1% in most populations. Micro-RNAs (miRNAs) are single-stranded, noncoding, short RNA molecules, they act as regulators of gene expression and play critical roles in many biological processes such as differentiation, development, and metabolism of the human-body cells.
Aim This case–control study aimed at detection of the expression of miRNA-224-3p in lesional skin of vitiligo patients as compared with normal-control persons to detect the possible role of miRNA-224-3p in the pathogenesis of vitiligo.
Patients and methods This study included 30 patients with vitiligo and 30 healthy controls. About 4-mm punch skin biopsy was taken from patients (vitiligo lesion) and controls and it was kept in lysis solution for the stability of the studied parameters and was kept frozen at −80°C till analysis of miRNA-224-3p by quantitative reverse-transcription-PCR.
Results The level of miRNA-224-3p in lesional skin of vitiligo was significantly higher as compared with normal-control persons.
Conclusion MiRNA-224-3p may play an important role in pathogenesis of vitiligo, so it can be used as a biomarker to evaluate its progression and effect of therapeutic interventions.
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